Provision of bacterial strains
Smaltis offers you bacterial strains from different collections, in order to allow you to use bacterial resources specifically adapted to your needs. These strains can be used directly in the manipulations that we implement for your projects, or can in some cases be transmitted to you so that you can conduct your experiments.
Collections of strains immediately available
Thanks to its collaboration with the Centre de Ressources Biologiques of the CHRU Jean Minjoz, Smaltis gives you access to more than 70,000 strains isolated from hospitalized patients suffering from various pathologies.
These clinical isolates are catalogued according to geography, year of isolation, resistance phenotype, sample source, and patient demographics.
Each strain is accompanied by the date and method of collection, the patient’s clinical conditions, the notion of an infectious outbreak (acute or chronic situation) and the prescription(s) of antibiotic therapy.
On the other hand, Smaltis offers to conduct work on reference strains from bioresource centers such as ATCC or DSMZ. Among the species we already have at our disposal are: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, Enterobacter species…
Genetically modified strains
Finally, thanks to its molecular biology platform, Smaltis has already built collections of genetically modified bacteria that can be used in your projects. These strains are characterized phenotypically and genotypically.
–P. aeruginosa mutants derived from the PAO1 strain, deleted from the genes coding for virulence factors and antibiotic resistance mechanisms
-Fluorescent P. aeruginosa strains
Under development: reference strains in which the main mechanisms of antibiotic resistance found in the clinic have been integrated into the genome, in order to be able to work on strains with a controlled genetic background. Among the targeted resistance mechanisms, we find active efflux, enzyme production, or mutation of antibiotic targets.
If your strain is not in the catalog, we can create it! (see our Strain Engineering offer)
Support service: conservation of strains
In addition, Smaltis provides its storage space specifically dedicated to bacteria, for an unlimited time. This storage is done under controlled temperature at -80°C, in a medium containing glycerol.